Lab-on-a-Printer™ technology was developed specifically to enable the biofabrication of highly complex, heterogeneous 3D tissue. This technology is embodied through a growing portfolio of disposable and modular microfluidic printhead cartridges, each offering sophisticated tissue design features. Utilizing the concept of coaxial flow focusing, a cell-laden biological fiber is generated within the printhead cartridge and patterned into a 3D structure. This unique 3D printing mechanism opens entirely new doors in the design of 3D printed tissue by allowing multiple different cell types to be precisely located or combined seamlessly during printing. Lab-on- a-Printer™ technology is compatible with a range of low and medium viscosity BioInks that are particularly well suited to promoting tissue function due to a combination of favorable mechanical properties and high ratios of bioactive and cellular content to scaffold components. Importantly, Lab-on- a-Printer™ technology is a forward looking platform that is able to harness rapidly growing advancements in microfluidics to reach the incredible levels of sophistication necessary to truly recapitulate the complexity of native organ tissue.
Multimaterial deposition and patterning is coordinated through our easy-to- use software and enables a high level of customization in 3D tissue design and fabrication. Users are able to easily define and visualize unique bioprinting toolpaths, include substructures with unique build properties, and customize other aspects of the tissue design.
Bioprinted using our Lab-on-a-Printer™ technology, the 3DBioRing™ tissue platform is uniquely capable of recreating the rapid contraction and relaxation of real human muscle tissues. The 3DBioRing™ tissue is fabricated from cell-loaded fibers to recreate natural muscle bundle morphology and cellular alignment. The 3DBioRing™ platform is broadly applicable to multiple contractile tissue types, the first powerful example, the 3DBioRing™ Airway, enables the user to investigate bronchoconstriction and relaxation at a tissue level in a physiologically-relevant and reproducible in vitro setting.