A revolutionary approach to regenerative medicine
We are combining our microfluidic 3D bioprinting technology with the incredible therapeutic potential of cells to develop bioprinted tissue therapeutics: first-in-class cell therapies designed to replace lost biological function, repair damaged tissue, and provide localized therapeutic delivery.
cell replacement
Bioprinting encapsulated cells to replace lost biological function
cell replacement
Bioprinting encapsulated cells to replace lost biological function
Treat disease by using cells to replace lost or missing function.
By bioprinting cell-loaded biomaterials, we can create encapsulated cell therapies and replace the function of lost or damaged tissue.
Our bioprinting technology offers several advantages for cell replacement, including:
- High cell viability – sensitive cells or cell aggregates undergo a gentle encapsulation process in supportive hydrogels to maintain high viability for long-term in vivo applications.
- Multifunctional cell encapsulation - biomaterials and cells are layered to combine functions such as immune protection, engraftment, and cell attachment.
- Scalability - high numbers of allogeneic cells can be encapsulated within a single 3D bioprinted implant using a scalable biomanufacturing method.
Example: Our work towards a bioprinted therapeutic for type 1 diabetes could replace the insulin release function of lost pancreatic cells. Learn more here.
tissue regeneration
Bioprinting to heal and repair damaged tissue
tissue regeneration
Bioprinting to heal and repair damaged tissue
Promote endogenous healing by bioprinting cells and biomaterials.
By combining the power of bioprinting with the body’s own regenerative abilities, we can give the body a head start on healing and restore a normal state of function.
Our bioprinting technology empowers tissue regeneration by:
- Rapidly switching and patterning – precise placement of cells and biomaterials can guide localized actions for targeted repair.
- Using fibres as building blocks – microfluidic printheads extrude hydrogel fibres that can mimic features and structure of native tissue.
- Bioprinting multicellular structures – inclusion of supporting cells, such as stromal or endothelial cells, can enhance the ability of a bioprinted therapeutic to promote tissue regeneration.
Example: Our partners are working towards applications such as a cardiac patch to enhance repair following a heart attack or implantable vascularized tissues for kidney regeneration and other applications in regenerative medicine.
cell-based delivery
Bioprinting engineered cells for localized therapeutic delivery
cell-based delivery
Bioprinting engineered cells for localized therapeutic delivery
Deliver and maintain functional cells in a specific location to establish long-lasting efficacy.
There is an industry recognized gap in delivering cells that maintain viability and therapeutic function.
Bioprinted therapeutics fill that gap by:
- Enabling the localization of therapeutic cells and, therefore, sustained therapeutic effect in a specific location
- Controlling the therapeutic dosage and duration of therapeutic effect
- Providing an option to retrieve the implanted cells
Example: Our work towards cell therapies for monogenic liver disorders aims to deliver engineered cells that produce the relevant therapeutic compound. Learn more here.
The Aspect Biosystem
Scientific & Technical Expertise
COMMITTED TO MAKING A REAL IMPACT
Through our in-house therapeutic programs, our R&D team has established a deep understanding of tissue engineering challenges and the development of cell-containing therapeutics.
Our team is dedicated to continuous innovation in order to make a difference in the lives of patients. We're always looking to add expertise to our growing team. Learn more!
Aspect Studio Software
BALANCING EASE OF USE WITH DESIGN FLEXIBILITY
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Designed to ensure ease of use while allowing total design freedom for greater customization
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Smooth integration between design and print functions enables easy tuning and optimization of your design
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Upgrades and training regularly provided to enable new functions and support new products
3D BIOPRINTING POWERED BY
MIGHTY MICROFLUIDICS
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Precise motion and pressure control enable microscale resolution at high speed
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Flexibility of microfluidics allows for seamless cell and material patterning
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User-friendly software drives the design of highly customized structures
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Engineered to be compatible with a wide range of biomaterials
RX1TM Bioprinter
Microfluidic Printheads
Empowering Unparalleled Creative Control
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Precise pressure and valve control provide seamless switching between multiple materials and fine control over fibre diameter with a single printhead
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On-printhead crosslinking allows printing of a wide range of materials with high print fidelity, including low viscosity bioinks to mimic soft tissue microenvironments
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Protective coaxial sheath minimizes shear stress on cells, which maintains high cell viability and preserves cell phenotype and function
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Selection of microfluidic printheads provide functional flexibility, including the ability to print cell-laden, multilayered concentric fibres with a hollow core for perfusion
Customizable Biomaterials
CREATING THE RIGHT ENVIRONMENT
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Incorporate various biological components to mimic microenvironments
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Print with high fidelity using low biomaterial concentrations to allow diffusion and achieve high cell densities
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Pattern biomaterial gradients and interfaces to better emulate biology
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Modulate tissue matrix stiffness while ensuring structural stability
